Augmenting amisulpride with clozapine had led to unmasking of akathisia
نویسندگان
چکیده
منابع مشابه
Clozapine augmentation with amisulpride.
A 42-year-old man with treatmentresistant schizophrenia presented a progressive clinical worsening under clozapine treatment (450 mg/d). He experienced worsening auditory hallucinations, increased distress and decreased working and social functioning (Positive and Negative Syndrome Scale [PANSS] score 97; positive subscale 21; negative subscale 31; general subscale 45). He experienced several s...
متن کاملAmisulpride has no effect on plasma clozapine concentrations.
To the Editors: To date, only a few systematic studies analyzing the use of combinations of antipsychotics have been undertaken. However, knowing how clozapine and amisulpride interact could be particularly important as patients with schizophrenia might well profit from such a combination treatment; indeed, a few case reports and studies support this notion. Good efficacy and tolerability of th...
متن کاملAugmentation of Clozapine With Amisulpride in Patients With Treatment-Resistant Schizophrenia An Open Clinical Study
Background: Therapeutic options for patients with treatment-resistant schizophrenia are limited. In such cases, a combination of atypical antipsychotic drugs is an often used strategy. We tested the hypothesis that the combination of amisulpride and clozapine would lead to long-term improvement in this patient group. Objective: 15 patients with treatment-resistant schizophrenia participated in ...
متن کاملAmisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions?
We report about a clinical observation in a well-characterized group of patients with obsessive-compulsive disorder (OCD) during an experimental medicine study in which a single dose of amisulpride (a selective D₂/₃ antagonist) was administered. Almost half of the OCD patients, in particular those with less severe obsessive-compulsive symptoms, experienced acute akathisia in response to the ami...
متن کاملAmisulpride in Addition to Clozapine: A Retrospective Study Indicates Improved Efficacy and Good Tolerability
Background: The common practice of augmenting the efficacy of clozapine by addition of amisulpride has some empirical and theoretical support, but has not been thoroughly investigated. Objective: We report on 14 patients (8 inpatients, 6 outpatients) with a mean age of 34.4 years (SD 8.6), who had received a combined clozapine/amisulpride treatment. 8 patients were suffering from schizophrenia ...
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ژورنال
عنوان ژورنال: Industrial Psychiatry Journal
سال: 2012
ISSN: 0972-6748
DOI: 10.4103/0972-6748.119638